GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs4663866 | 1 | rs4663866 | chr2:239150815 | LOC151174 | chr2:239133754-239140318:- | 0.49 | 5.27 | 2.07E-7 | Irritable bowel syndrome |
| THCA | cis | rs4663866 | 1 | rs4663867 | chr2:239159964 | LOC151174 | chr2:239133754-239140318:- | 0.5 | 5.41 | 9.97E-8 | Irritable bowel syndrome |
| THCA | cis | rs4663866 | 1 | rs4663868 | chr2:239161091 | LOC151174 | chr2:239133754-239140318:- | 0.49 | 5.34 | 1.41E-7 | Irritable bowel syndrome |
| THCA | cis | rs4664308 | 1 | rs4664308 | chr2:160917497 | LY75 | chr2:160625141-160761262:- | 0.21 | 4.84 | 1.8E-6 | Idiopathic membranous nephropathy |
| THCA | cis | rs4664308 | 1 | rs4665147 | chr2:160917062 | LY75 | chr2:160625141-160761262:- | 0.21 | 4.82 | 1.95E-6 | Idiopathic membranous nephropathy |
| THCA | cis | rs7608623 | 1 | rs4665238 | chr2:23942446 | C2orf84 | chr2:24397531-24414566:+ | -0.2 | -3.36 | 0.000835 | Obesity-related traits |
| THCA | cis | rs7608623 | 1 | rs4665238 | chr2:23942446 | LOC375190 | chr2:24299728-24397519:+ | 0.31 | 7.89 | 2.12E-14 | Obesity-related traits |
| THCA | cis | rs4665809 | 1 | rs4665298 | chr2:26256378 | GPR113 | chr2:26531041-26569685:- | -0.41 | -6.52 | 1.79E-10 | Gut microbiome composition (summer) |
| THCA | cis | rs4665809 | 1 | rs4665299 | chr2:26256840 | GPR113 | chr2:26531041-26569685:- | -0.48 | -7.38 | 6.94E-13 | Gut microbiome composition (summer) |
| THCA | cis | rs4665809 | 1 | rs4665299 | chr2:26256840 | HADHA | chr2:26413505-26467594:- | -0.16 | -3.35 | 0.000877 | Gut microbiome composition (summer) |
| THCA | cis | rs4665809 | 1 | rs4665304 | chr2:26313406 | GPR113 | chr2:26531041-26569685:- | -0.42 | -6.8 | 3.04E-11 | Gut microbiome composition (summer) |
| THCA | cis | rs4665809 | 1 | rs4665305 | chr2:26313524 | GPR113 | chr2:26531041-26569685:- | -0.41 | -6.58 | 1.25E-10 | Gut microbiome composition (summer) |
| THCA | cis | rs4665809 | 1 | rs4665305 | chr2:26313524 | HADHA | chr2:26413505-26467594:- | -0.16 | -3.38 | 0.000787 | Gut microbiome composition (summer) |
| THCA | cis | rs4665809 | 1 | rs4665306 | chr2:26319124 | GPR113 | chr2:26531041-26569685:- | -0.45 | -7.05 | 6.34E-12 | Gut microbiome composition (summer) |
| THCA | cis | rs4665809 | 1 | rs4665308 | chr2:26330514 | GPR113 | chr2:26531041-26569685:- | -0.42 | -6.71 | 5.42E-11 | Gut microbiome composition (summer) |